抗生素的药效动力学Pharmacodynamics of Antibiotics.pptVIP

Pharmacodynamics of Antibiotics;Concepts;Minimum Inhibitory Concentration (MIC) The lowest concentration of an antibiotic that inhibits bacterial growth after 16-20 hrs incubation. Minimum Bacteriocidal Concentrations. The lowest concentration of an antibiotic required to kill 99.9% bacterial growth after 16-20 hrs exposure. C-p Peak antibiotic concentration Area under the curve (AUC) Amount of antibiotic delivered over a specific time.;Antimicrobial-micro-organism interaction;Static versus Cidal;Questions;Can this antibiotic inhibit/kill these bacteria?;;Post-antibiotic sub-MIC effect. Prolon