抗生素话题(英文课件)Topical Antibiotics.pptVIP

Historical: Aminoglycosides Waksman and Schatz demonstrated the antibacterial activity of Streptomyces griseus in 1943 Streptomycin isolated in 1944 Neomycin isolated from Streptomyces fradiae in 1949 Neomycin Neomycin is extremely nephrotoxic, thus limiting its use to a topical antibiotic Neomycin has excellent activity against gram negative bacteria and partial activity against gram positive strains Some people have allergies to neomycin Like other aminoglycosides, neomycin works by binding to the bacterial 30S ribosomal subunit, thus inhibiting protein synthesis. Topical Antibiotics Topi