抗生素课件课件(英文精品) Miscellaneous Antibiotics.pptVIP

Miscellaneous Antibiotics Polymyxins Active against gram-negative including pseudomonas. Polymyxin B is only available. Bactericidal inhibits cell wall synthesis. Used only topically . Highly nephrotoxic. Spectinomycin Bactericidal ,inhibits protein synthesis by binding to 30S ribosomal subunits. Active against gram positive gram negative organisms. Rapidly absorbed after intramuscular injection. Excreted through kidney . Clinical uses As an alternative treatment for drug- resistant gonorrhea or gonorrhea in penicillin –allergic patients. No cross-resistance with other drugs used in gon