抗生素耐药的机理(英文课件).pptVIP

AmpC ?-Lactamases Produced by almost all gram-negative bacteria Chrosomally encoded versions important in Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Morganella morganii, Pseudomonas aeruginosa and Serratia marcescens (not found in Salmonella and Klebsiella) AmpC ?-Lactamase genes have been found on transferable plasmids Class C ?-Lactamases All ?- lactams induce AmpC ?-lactamase production Only carbapenems are resistant to AmpC ?-lactamases If there is loss of porins as well, this will lead to carbapenem resistance Other ?- lactams will be hydrolysed Metallo-?-Lacta