抗生素英文课件精品——Antibiotic dosage regimen based on PK-PD concepts and the possible minimization of resistance.ppt

In the early 1990s New York City experienced an outbreak of MDR tuberculosis. At the time we were studying DNA topoisomerases to better understand chromosome structure. We had used quinolones as tools, and so we were familiar with them. During the outbreak it became clear that the use of ciprofloxacin quickly led, sometimes within a month, to ciprofloxacin-resistant tuberculosis (13, 17). At the time it seemed that the problem was to find a way to halt the development of resistance. From a na?ve microbiological point of view we thought that we should look for new quinolones that would r