抗生素英文课件精品——Antibiotic Update 2009.pptVIP

Current Antifungal Agents Structure Mechanism of Action Primary Use Ampho B ergosterol inhibition moulds/dimorphic fungi Terbinafine cutaneous infxn Azoles ergosterol inhibition dimorphic fungi, Fluc Candida, Itra Aspergillus Vori Posa Echinocandins inhibit glucan synthesis Candida/ Micafungin Aspergillus Caspofungin Anidulafungin Azole Antifungal Agents Two major types Imidazoles– ketoconazole, miconazole Triazoles- Fluconazole, Itraconazole, Posaconazole, Voraconizole Major limiting adverse effect- hepatotoxicity Lots of potential drug inter