抗生素英文课件精品——Microbiology Principles and Explorations.pptVIP

Microbiology: Principles and Explorations Sixth Edition;Antimicrobial Agents;1910: Paul Ehrlich used Salvarsan to treat syphilis 1935: Gerhard Domagk discovered prontosil, a red dye, inhibits growth of many gram-positive bacteria 1936: Ernest Fourneau discovered that the sulfanilamide portion contained antimicrobial activity;Selective Toxicity The Spectrum of Activity Modes of Action Side Effects The Resistance of Microorganisms;The antimicrobial agent must harm the microbes without causing significant damage to the host Toxic dosage level: causes host damage Therapeutic dosage level: succes