脓毒血症的抗生素治疗(英文课件)Antibiotics for Severe Sepsis and Septic Shock.pptVIP

* * * * Double Gram Negative Coverage? Safdar, et al – Meta-analysis of 3077 pts across 17 studies – 2 out 17 studies found benefit, 1 found increased mortality, 14 showed no benefit* Prospective Studies were separated out and still no benefit Cochrane Review of 7586 pts comparing PCN + AG to PCN alone for Gram neg sepsis – No mortality benefit** *Safdar, et al. Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? A meta-analysis. Lancet Infect Dis. 2004 Aug;4(8):519-27. **Paul M, et al. Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside ant