(精编)【体外膜肺ECMO精品课件】 Bunyaviridae教学课件.pptVIP

Rift Valley FeverDistribution Map Crimean-Congo Hemorrhagic FeverNairovirus Transmitted by ticks Appears in the Middle East and Africa Targets the liver and vascular endothelium Symptoms include: Headache Pain in limbs Often bleeding from many orifices Crimean-Congo Hemorrhagic FeverNairovirus Hantavirus Enveloped ssRNA Virions 98 nm in diameter Genome consists of three RNA segments TransmissionVectors Transmitted via aerosolized rodent urine, feces, and saliva Deer mouse (Peromyscus maniculatus) Cotton rat (Sigmodon hispidus) White-footed mouse (Peromyscus leucopus) Striped field mours (Apodemus agrarius) Bank vole (Clethrionomys glareolus) Rat (Rattus) Hemorrhagic Fever with Renal SyndromeHantavirus Liver and vascular enothelium are targeted Symptoms include: Hemorrhage Acute renal failure Fever Over 15% mortality rate Hantavirus Pulmonary SyndromeHantavirus Lungs are targeted Symptoms include Fever Acute respiratory distress Over 50% mortality rate Shock and cardiac complications often contribute to death Bunyaviridae Clayton M. Johnston Bunyaviridae Largest family of mammal affecting viruses (250 viruses) Arthropod- or rodent-borne vectors Most are amplified in vertebrate hosts Bunyaviridae Genus Disease(s) Bunyavirus LaCrosse encephalitis Phlebovirus Rift Valley Fever Nairovirus Crimean-Congo Hemorrhagic Fever Tospovirus Plant Virus Hantavirus Hemorrhagic Fever with Renal Syndrome Hantavirus Pulmonary Syndrome Structure Virion Structure Genomic Structure Structural Proteins Structural Proteins Membrane glycoproteins (G1 and G2) Nucleocapsid proteins (N) Polymerase (L) Membrane Glycoproteins G1 and G2 Integral membrane proteins Important in cell entry and pathogenesis Nucleocapsid Protein Complexes with genomic vRNA in virus, as well as with cRNA after infection, but not with mRNA Necessary for virus replication and packaging Viral Polymerase RNA-dependent RNA polymerase Complexed with ribonucleocapsid in virion Endonuclease activity to cleave