(精编)【医学英文课件】 IRON IRON OVERLOAD教学课件.pptVIP

WHY DO MDS PATIENTS DEVELOP TOO MUCH IRON? Each unit of packed RBC (red blood cell) contains about 250mg of iron! 2 units = 500mg 10 units = 2500mg 20 units = 5000mg Recall that the daily amount of iron lost in the body is only 1-2mg and the total body iron is 3000-5000mg. Steensma DP and Bennett JM. The Myelodysplastic Syndromes: Diagnosis and Treatment. Mayo Clin Proc. 2006;81(1):104-130. Oct 29, 2016 C. Hsia * Free Iron: The Essence of Iron Overload Oct 29, 2016 C. Hsia * 100% 30% Normal: no NTBI produced Iron overload Subsequent formation of NTBI in plasma Saturation of transferrin du