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60yo woman with h/o OA has labs drawn BUN=24, Cr 1.8. U/A reveals 20 WBC, no bacteria. What is the cause of ARF? Pre renal azotemia secondary to UTI ATN secondary to Abx AIN secondary to NSAID use Acute glomerulonephritis WBC CAST Acute Interstitial Nephritis 70% Drug hypersensitivity 30% Antibiotics: PCNs (Methicillin), Cephalosporins, Cipro Sulfa drugs NSAIDs Allopurinol... 15% Infection Strep, Legionella, CMV, other bact/viruses 8% Idiopathic 6% Autoimmune Dz (Sarcoid, Tubulointerstitial nephritis/Uveitis) AIN from Drugs Renal damage is NOT dose-dependent May take wks after initial
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