(精编)BI302-_lecture7 - MiNDS教学课件.pptVIP

Bacteriology lecture 7: Antimicrobial drugs and introduction to disease Bacteria Become Resistant to Antibiotics by: 1) Ceasing to produce the drug-sensitive structure e.g. there are mutant strains of Staphylococcus which do not have a cell wall and which are resistant to antibiotics which inhibit cell wall synthesis. 3) Becoming impermeable to the drug e.g. mutants with altered membrane structure. 2) Modifying the sensitive structure e.g. strains with altered ribosomes which are resistant to antibiotics which inhibit protein synthesis. 4) Releasing enzymes that inactivate the antibiotic e.g