(精编)Fig. 13-1教学课件.pptVIP

Microbiology: Principles and Explorations Sixth Edition;Antimicrobial Agents;1910: Paul Ehrlich used Salvarsan to treat syphilis 1935: Gerhard Domagk discovered prontosil, a red dye, inhibits growth of many gram-positive bacteria 1936: Ernest Fourneau discovered that the sulfanilamide portion contained antimicrobial activity;Selective Toxicity The Spectrum of Activity Modes of Action Side Effects The Resistance of Microorganisms;Inhibition of cell wall synthesis Disruption of cell-membrane function Inhibition of protein synthesis Inhibition of nucleic acid synthesis 5. Action as antimetabolit