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* Their broad spectrum of activity and safety profile make the cephalosporins one of the most widely prescribed class of antimicrobials. The earlier generation cephalosporins are commonly used for community-acquired infections, while the later generation agents, with their better spectrum of activity against gram-negative bacteria make them useful for hospital-acquired infections or complicated community-acquired infections. The Professor of Hygiene of the University of Cagliari, Giuseppe Brotzu (1895-1976), wondered why typhoid fever was less virulent in his city than elsewhere. He had form