Electronic Posters Molecular：电子海报分子.docVIP

Electronic Posters: Molecular Cell Tracking I Hall B Monday 14:00-16:00 Computer 67 14:00 4166. Monitoring the Uptake of 19F Nanoparticles and in Vivo Migration of Dendritic Cells Using Magnetic Resonance Helmar Waiczies1,2, Bettina Erdmann3, Bernd Ittermann1,2, Frank Seifert1,2, Thoralf Niendorf, 2,4, Sonia Waiczies, 2,5 1Physikalisch Technische Bundesanstalt, 10587 Berlin, Germany; 2Berlin Ultrahigh Field Facility, Max-Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany; 3Electron Microscopy, Max-Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany; 4Experimental and Clinical Research Center (ECRC), Charité Campus Buch, Humboldt-University, 13125 Berlin, Germany; 5Department of Hematology and Oncology, Charité Campus Buch, Humboldt-University, 13125 Berlin, Germany 19F cellular magnetic resonance imaging (MRI) provides signal selectivity during cell tracking and a possibility to overlay 19F-labeled cells with anatomic 1H scans. This work investigates the uptake of nanoparticles containing perfluoro-15-crown-5 ether in dendritic cells and their impact on cell function. 19F MR spectroscopy and electron microscopy showed a rapid and efficient uptake of nanoparticles by DC. The 19F signal intensity in these cells was shown to be directly related to 19F nanoparticle size. 19F/1H MRI showed that DC function was not disturbed following 19F-labeling as demonstrated by an efficient migration of these cells into draining popliteal lymph nodes. 14:30 4167. Long Term Evaluation of the 1.28 Ppm After Transplantation of Purified Neural Progenitor Cells in the Brain Chiao-Chi V. Chen1, Kuan-Chi Mo1, Ching-Yu Chuang2, Hung-Chih Kuo3, Chen Chang1 1Functional and Micro-magnetic Resonance Imaging Center, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 2Institute of Biotechnology, National Taiwan University, Taipei, Taiwan; 3Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan The present study aimed to use in vivo MR