外周血造血干细胞移植治疗恶性血液病8例疗效观察.docVIP

HLA全相合与不全相合异基因造血干细胞移植 治疗血液病56例疗效观察 黄晓靓 王季石 卢英豪 孙志强 张燕 赵鹏 张开基 李梦醒 谢润兰 （贵阳医学院附属医院血液科，贵州省造血干细胞移植中心 贵州省血液病诊疗中心实验室贵阳，550004） **通讯作者：王季石Email：jswang_yg@ 摘要 目的：探讨HLA不全相合异基因造血干细胞移植(PBSCT)治疗血液病的可行性。方法：回顾性分析了我院自2008年12月～2012年4月采用异基因造血干细胞移植(allogene blood stem cell transplantation HSCT)治疗56例血液病患者的临床资料；其中男35例,女21例 ,年龄 8～62岁 ,中位年龄 40 岁。其中例例。无严重GVHD graft versus host disease）发生, 无严重并发症发生,Clinical observation of 56 patients with hematologic diseases treated by allogene blood stem cell transplantation HUANG Xiao-liang, WANG Ji-shi，LU Ying-hao，SUN Zhi-qiang，ZHANG Yan，ZHANG Kai-ji，LI Meng-xing，XIE Run-lan，LONG Zheng-mei. (Department of hematology affiliated hospital of Guiyang Medical College,The hematopoietic stem cell transplant center of Guizhou Province,blood diseases diagnosis and treatment center of Guizhou Province,Guiyang 550004，China) **Corresponding author :jishi Wang Email：jswang＿yg@ Abstract Objective：To objective the effect of allogene blood stem cell transplantation(allo-HSCT) in the treatment of hematologic diseases and explore the issue about the prevention and treatment for complications correlated with PBSCT. Methods：Date of 56 patients with hematologic diseases treated by allo-HSCT from 2008.12 to 2012.04 in our hospital were retrospectively analyzed.Including 35 male ,21 female ,aged 8 to 62 years old ,the median age was 40 years old. 基金项目：2010年国家自然科学基金项目；贵州省社会攻关项目基金（黔科合SY字[2011]3012号）；贵州省省长基金（黔省专合字（2010）84号）；贵州省科技厅对外合作项目（黔科合外G字[2011] 7010号）。 33 patients(5 cases of acute lymphoblastic leukemia , 15 cases of acute myeloid leukemia，6 cases of chronic myeloid leukemia,4 cases of acute severe aplastic anemia ,1 cases of multiple myeloma) were treated with HLA- Full matched allogenic blood stem cell transplantation (Allo-HSCT) and 23 patients(10 cases of acute lymphoblastic leukemia，4 cases of acute myeloid leukemia，5 cases of chronic myeloid leukemia ) were treated with HLA-halfmatched allogenic blood stem cell transplantation (Allo-HSCT) Results：Al