微喷技术在生物医药领域的应用_孙怀远.pdfVIP

综述文章（Reviews ） 微喷技术在生物医药领域的应用 1,2 1 2 2 孙怀远 ，周玉栋 ，廖跃华 ，杨丽英 1. 上海理工大学医疗器械与食品学院，上海 200093 2. 上海医疗器械高等专科学校，上海 200093 摘要 微喷射是微流体控制系统的一个重要组成部分，是微量流体在惯性力与黏性力交替作用下实现的脉冲流动。 微喷射流体的 驱动技术和与驱动技术相应的微喷嘴制造技术是微喷射过程正常实现所需要的两项关键技术支撑。 作为一种新型的工艺，数字化 微喷射技术在微机械和微器件制造、医学、生物工程、制药工程等领域获得了一定发展和初步应用。 本文从微喷射的原理出发，介 绍微喷技术及其应用范围，并结合图例叙述数字化微喷技术在生物芯片微阵列制备、细胞显微注射、药物涂层心脏支架生产、微胶 囊制造、可控释放药物制造等生物医药领域的应用及其特点，指出微喷技术发展的研究方向以及应用研究的重要意义。 关键词 微喷技术；生物；医药 中图分类号 文献标识码 文章编号 （ ） Q81 A 1000-7857 2010 20-0097-04 Development of Microinjection Technique in Biomedicine Field 1,2 1 2 2 SUN Huaiyuan , ZHOU Yudong , LIAO Yuehua , YANG Liying 1. School of Medical Instrumentation and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China 2. Shanghai Medical Instrumentation College, Shanghai 200093, China Abstract Microinjection is an integral component of systems to administer microfluids. The pulsating flow of a microfluid is caused by alternations between the inertia and viscous forces. Drive technology and manufacturing technology of micropipettes are two key factors that regulate the microinjection process. The digital microinjection technique has been a focus of much research and development in the fields of micro-machine and microcomponent technology, medicine, biological engineering and pharmaceutical engineering. In this paper, we discuss the recent research and developments in the field of microinjection, and its application. This paper describes the application and features of digital microinjection techniques as they pertain to bio-chip microarray manufacturing, cell microinjection, production of drug -eluting stents, manufacture of microcapsules, and controlled release o