蒲元和胃胶囊联合莫沙必利和泮托拉唑治疗反流性食管炎的疗效观察.pdf

·628 · 现代药物与临床 Drugs Clinic 第 32 卷 第 4 期 2017 年 4 月 蒲元和胃胶囊联合莫沙必利和泮托拉唑治疗反流性食管炎的疗效观察 孟 敏，王秀敏，黄佩杰，黄宏春 安阳市人民医院 消化内科，河南 安阳 455000 摘 要：目的 探讨蒲元和胃胶囊联合莫沙必利和泮托拉唑治疗反流性食管炎的临床疗效。方法 选取安阳市人民医院 2013 年 10 月—2016 年 10 月收治的 102 例反流性食管炎患者，随机分为对照组和治疗组，每组各 51 例。对照组患者饭前口服枸 橼酸莫沙必利片，1 片/次，3 次/d ；同时早晨空腹口服泮托拉唑钠肠溶片，1 片/次，1 次/d 。治疗组患者在对照组的基础上 于饭后 1 h 口服蒲元和胃胶囊，4 粒/次，3 次/d 。两组患者均连续治疗6 周。评价两组患者临床疗效，比较治疗前后两组患 者生活质量和临床症状评分。结果 治疗后，对照组的总有效率为 84.31%，显著低于治疗组的 96.08%，两组比较差异有统 计学意义（P ＜0.05 ）。治疗后，两组患者各项生活质量评分均较治疗前明显升高，临床症状评分均显著降低，同组治疗前后 比较差异有统计学意义（P ＜0.05 ）；且治疗组患者生活质量和临床症状评分改善程度显著优于对照组，两组比较差异有统计 学意义（P ＜0.05 ）。结论 蒲元和胃胶囊联合莫沙必利和泮托拉唑治疗反流性食管炎疗效显著，安全性较高，具有一定的临 床推广应用价值。 关键词：蒲元和胃胶囊；枸橼酸莫沙必利片；泮托拉唑钠肠溶片；反流性食管炎；生活质量评分；临床症状评分 中图分类号：R975 文献标志码：A 文章编号：1674 - 5515(2017)04 - 0628 - 04 DOI: 10.7501/j.issn.1674-5515.2017.04.017 Clinical observation of Puyuan Hewei Capsules combined with mosapride and pantoprazole in treatment of reflux esophagitis MENG Min, WANG Xiu-min, HUANG Pei-jie, HUANG Hong-chun Department of Gastroenterology, the People’s Hospital of Anyang, Anyang 455000, China Abstract: Objective To evaluate the clinical efficacy of Puyuan Hewei Capsules combined with mosapride and pantoprazole in treatment of reflux esophagitis. Methods Patients (102 cases) with reflux esophagitis in the People’s Hospital of Anyang from October 2013 to October 2016 were randomly divided into control and treatment groups, and each group had 51 cases. Patients in the control group werepo administered with Mosapride Citrate Tablets before meals, 1 tablet/time, three times daily. And they were fasting po administered with Pantoprazole sodium Enteric-Coated Tablets at the same time, 1 tablet/time, once daily. Patients in the treatment group were po administered with Puyuan Hewei Capsules on the basis of the control group 1 h after meals, 4 grains/time, three times daily. Patient