ce for peace and security series b physics and biophysics] functionalized nanoscale materials, devices and systems strontium-substituted hydroxyapatite thin films grown by pulsed laser deposition文档.pdf

STRONTIUM-SUBSTITUTED HYDROXYAPATITE THIN FILMS GROWN BY PULSED LASER DEPOSITION 1* 2 2 1 C. CAPUCCINI , F. SIMA , E. AXENTE , E. BOANINI , 3 1 2 M. GAZZANO , A. BIGI , AND I.N. MIHAILESCU 1 Biomimetics and Materials Chemistry Laboratory, Department of Chemistry, Bologna, ITALY 2Laser-Surface-Plasma Interactions Laboratory, Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, PO Box MG-54, Bucharest-Magurele, ROMANIA 3ISOF-CNR, c/o Department of Chemistry “G. Ciamician”, Bologna, ITALY Abstract – Strontium substitution for calcium in the hydroxyapatite structure has lately attracted growing interest due to its beneficial effects on both bone formation and prevention of bone resorption. Coating Ti implants with Sr2+- substituted hydroxyapatite is expected to enhance the bioactivity of the surface and stimulate bone apposition. To this end, we deposited thin films of hydroxya- patite with different substitutions of Sr2+ for Ca2+ on Ti substrates by Pulsed Laser Deposition (PLD). Solid solutions of Sr-Ca hydroxyapatites Ca10-xSrxHA (x = 0–1) were prepared by direct synthesis in aqueous medium at 90°C. Sr2+ insertion led to a decrease of crystallinity degree, which accounted for the simultaneous reduction of the crystal dimensions. For PLD experiments, we used an UV excimer (KrF*) laser source (248 nm, ~7.4 ns) operating at a repetition rate of 2 Hz. The fluence during target irradiation was set at 2.4 J/cm2, and substrate temperature kept