先心病 (31y)典型实例.pptVIP

Heart - Pathology Congenital Heart Disease MC type of heart disease among children MC type= VSD Etiology and Pathogenesis Multifactorial = majority of cases Developmental Trisomy 21 (Down syndrome) MC known genetic cause Endocardial cushion defects (AVSD) ASD Di -George syndrome with TOF Environment= infection (congenital rubella) or teratogens Heart - Pathology Congenital Heart Disease Clinical Features Malformations causing left-to-right shunt right-to-left shunt Obstruction Mechanisms - left-to-right shunt Type of Defect Mechanism Ventricular Septal Defect (VSD) hole within