mirna一类新的调控微小rna-生命科学研究-湖南师范大学.pdf

6 4 ( ) 生命科学研究 Vol. 6 No.4(Suppl.) 2002 12 Life Science Research Dec. 2002 X miRNA ) RNA 孙亚兰, 袁婺洲, 吴秀山 ( 410081) :在线虫 C . elegans 的发育过程中, 时序调节微小RNA 起 很重要的作用. 其中有两种关键基因lin 4 和 let 7长约22 个核苷酸, 不编码蛋白质, 参与基因表达的负调节, 这可能是翻译水平上的调节与发生在转录后的 RNA 干涉不同. 研究表明它们在大小结构和功能上具有保守性. 主要从miRNA 的发现分布形成作用 4 个 方面进行了综述. :微小RNA; 时序调节微小RNA; 异时表型 : Q756 :A : 1007 7847(2002) S1 0106 04 miRNA) A New Group of Small Temporally Regulated RNAs SUN Ya lan, YUAN Wu zhou,WU Xiu shan ( College of Lfi e Sciences,H unan Normal Univ ersity , Chang sha 410081,H unan , China) Abstract: During the development of the nematode C . eleg ans , two small temporally regulated RNAs ( stRNA) reg ulate timing of gene expression. Two of the stRNAs, lin 4 and let 7 are of about 22 nucleotides, nocoding protein, and are very important during the downregulation of gene expression. This regulation occurs at a posttranscriptional, presumably translational level and is distinct from RNA interference. Researches suggested that they are conserved in size, structure and function. The discovery, distributing, form and function of miRNA are mainly reviewed. Key words: miRNA; stRNA; , heterochronic phenortypes (Lfi e Science Research , 2002, 6( Suppl) : 106~ 109) . 1 miRNA miRNA [ 1] , . mi