葛根及葛根素脑保护作用的研究进展-河南农业科学.pdfVIP

※专题论述 食品科学 2015, Vol.36, No.17 259 葛根及葛根素脑保护作用的研究进展 魏述永 （西南大学荣昌校区动物医学系，重庆 402460 ） 摘  要：葛根为我国传统的药食两用植物，葛根素为其主要药效成分之一。依据中医药理论，葛根具有解表退热、 生津止渴的功效。现代药理学研究表明，葛根及葛根素均具有显著的脑保护活性，对阿尔茨海默病、帕金森病及脑 卒中等模型动物或细胞产生保护作用，其机制与调节GSK-3β/Nrf2 、PI3K/Akt 、cAMP/PKA等神经细胞凋亡信号转 导通路有关。提示葛根具备开发为抗神经系统疾病保健食品的潜在价值。 关键词：葛根；葛根素；脑保护；保健食品 Progress in Cerebral Protection of Pueraria lobata (Willd.) Ohwi (Fabaceae) and Puerarin WEI Shuyong (Department of Veterinary Medicine, Rongchang Campus, Southwest University, Chongqing 402460, China) Abstract: Pueraria lobata (Willd.) Ohwi (Fabaceae), a traditional edible and medicinal plant in China, is used in in traditional Chinese medicine. Puerarin is one of its most important and effective components. According to the traditional Chinese medicinal theory, the roots of Pueraria lobata (Willd.) Ohwi (Fabaceae) have many functions such as relieving exterior syndrome, reducing fervescence, promoting the secretion of saliva or body fluid, and quenching thirst. Modern pharmacological research suggest that both Pueraria lobata (Willd.) Ohwi (Fabaceae) and puerarin exert cerebral ’ ’ protections in animal or cell models of Alzheimer s disease, Parkinson s disease and stroke, and the mechanisms involved may be associated with regulating the GSK-3β/Nrf2, PI3K/Akt and cAMP/PKA apoptosis signal pathways. These results indicate that Pueraria lobata (Willd.) Ohwi (Fabaceae) has the potential to be developed into health foods against nervous system diseases. Key words: Pueraria lobata (Willd.) Ohwi (Fabaceae); puerarin; cerebral protection; health food 中图分类号：R285.5 文献标志码