植物表观遗传学研究报告.pptVIP

Maintenance of CG DNA methylation MET1 HDA6 (HISTONE DEACETYLASE 6) DDM1 Maintenance of CNG methylation CMT3, KYP(KRYPTONITE) /SU(VAR)3-9 HOMOLOG 4 (SUVH4) AGO1 DsRNA AGO1 KYP CMT3 CNG Me CHH Me siRNAs DCL3 ~24bp TGS: RNA-directed DNA methylation Inverted DNA R Pol II Me Me Me MET1? DRM2 MET1 HDA6 CG Me DDM1 DNA RNA pol IV RDR2 Me Me Me CG CNG CHH AGO4 DRD1 DRM2 Specific DNA methylation loci in Arabidopsis Chan et al., Nat Rev Genet. 2005 6:351-60. (pathogen related) Wassilewskija strain Arabidopsis tryptophan enzyme phosphoribosylanthranilate isomerase (PAI) S15a promoter+ first exon P