Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography.[2017][IEEE Trans Med Imaging][10.1109tmi.2017.2686006]精选.pdfVIP

This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Citation information: DOI 10.1109/TMI.2017.2686006, IEEE Transactions on Medical Imaging 1 Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography ´ ´ ´ Lu Ding, Xose Luıs Dean-Ben, Neal C. Burton, Robert W. Sobol, Vasilis Ntziachristos, and Daniel Razansky* Abstract—Accurate extraction of physical and biochemical MSOT images representing the distribution of spectrally- parameters from optoacoustic images is often impeded due to distinct chromophores are generally obtained with a two-step the use of unrigorous inversion schemes, incomplete tomographic procedure. In a first step, optoacoustic tomographic images are detection coverage or other experimental factors that cannot be readily accounted for during the image acquisition and recon- reconstructed from the pressure signals generated by absorp- struction process. For instance, inaccurate assumptions in the tion of short laser pulses. The signals are recorded at several physical forward model may lead to negative optical absorption locations around the imaged object while various inverse values in the reconstructed images. Any artifacts present in algorithms based on back-projection [16], time-reversal [17] the single wavelength optoacoustic ima