分子生物学：细胞信号_研究与研讨生课件.ppt

Chapter 6 Cell Signal Transduction (Part Ⅱ);6. VEGF Receptor Signal Transduction;Molecular Structure of VEGF;;人VEGF-A有六种不同的异构体，由同一mRNA前体剪接而来。;Isoforms of Vascular Endothelial Growth Factor A (VEGF-A);6.2 VEGF Receptor;VEGF Receptor Family;VEGFR与其配体结合后，胞内区受体TPK被激活，对多种底物蛋白/酶进行磷酸化修饰以传递生长信号。 可被VEGFR激活的信号转导途径包括PLC?-PKC途径、Ras-MAPK途径、PI3K-PKB途径等。;VEGFR Signal Transduction Pathways;Section 9 Signal Transduction System by Insulin Receptor;1. Structure and Function of Insulin Receptor;Molecular Structure of Insulin Receptor;Phosphorylation of Insulin Receptor;当胰岛素受体与其配体结合后，即可使受体TPK活化，催化受体蛋白酪氨酸残基