characterization of interfacial hydrodynamics in of a single cell of shaken microtiter plate bioreactors applying computational fluid dynamics technique推荐.pdf

Available online at Procedia Engineering 42 ( 2012 ) 924 – 930 th 20 International Congress of Chemical and Process Engineering CHISA 2012 25 – 29 August 2012, Prague, Czech Republic Characterization of interfacial hydrodynamics in a single cell of shaken microtiter plate bioreactors applying computational fluid dynamics technique a,b a,b,c d b,c B. Pouran , G. Amoabediny a*, M. Sadegh Saghafinia , M. P. Haji Abbas aDepartment of Biotechnology, School of Chemical Engineering, University of Tehran, Tehran P.O. Box 1155/4563, Iran bDepartment of Bioreactor and Screening Engineering, Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran P.O. Box 1155/4563, Iran cDepartment of Life Science Engineering, Faculty of New Technologies, University of Tehran, Tehran P.O. Box 14179, Iran dDepartment of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran P.O. Box 11365-11155, Iran Abstract Development of orbital shaking technology for enhanced mixing with lower mechanical demand has been receiving significant attention since the advent of advanced mixing schemes. Amongst shaken bioreactors,microtiter plates play significant role both for research and industrial purposes due to their capability of handling tiny amount of liquid in parallel experimentations. Detailed understanding of complicated Flow hydrodynamics thus seems to be considered a continual effort, as