非编码rna调控上皮间充质化及肿瘤干细胞的研究进展.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(11): 1584– 1591 DOI: 10.11844/cj cb.2014.11.0176 非编码RNA调控上皮间充质化及肿瘤 干细胞的研究进展 1,2 1 1* 杨 琼 李永君 方向东 1 ( 中国科学院北京基因组研究所, 中国科学院基因组科学与信息重点实验室, 北京100101; 2 中国科学院大学, 北京100049) 摘要 肿瘤干细胞是具有自我更新能力并能发展成为不同分化程度的肿瘤的一类细胞, 它 的存在是肿瘤转移和复发的重要原因。最新研究表明, 肿瘤干细胞可通过肿瘤细胞的上皮– 间充质 化(epithelial-mesenchymal transition, EMT)产生。作为研究细胞调控的热点—非编码RNA, 通过 调控EMT可能会促使肿瘤细胞获得肿瘤干细胞特征。该文主要综述了近年来非编码RNA调控肿 瘤细胞EMT以及干性获得的研究进展, 以有助于理解肿瘤中非编码RNA 的调控机制和功能。 关键词 上皮间充质化; 非编码RNA; 肿瘤干细胞 Advances of Non-coding RNAs Regulation in Epithelial-mesenchymal Transition and Cancer Stem Cells 1,2 1 1* Yang Qiong , Li Yongjun , Fang Xiangdong 1 ( Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; 2 University of Chinese Academy of Sciences, Beijing 100049, China) Abstract Cancer stem cells (CSCs), possessing self-renewal properties and the capacity to differentiate into the heterogeneous cancer populations, play an important role in tumor metastasis and relapse. It is reported that cancer stem cells can be generated when cancer cells go through epithelial-mesenchymal transition (EMT). Non- coding RNAs (ncRNAs), as key regulators of gene expression, could contribute to the acquisition of stem cell trait by regulating EMT process. This review focused on current understanding of the regulation mechanisms of EMT in CSCs formation and th