《阿斯匹林与毛瘤》.pptVIP

汇报者：吕红莉 2006.09.02 阿斯匹林 与 多发性家族性毛发上皮瘤 疾病简介：概况 临床表现 治疗 阿斯匹林治疗多发性家族性毛发上皮瘤（MFT)的疗效。 MFT致病基因CYLD编码蛋白CYLD蛋白功能。 阿斯匹林治疗MFT的机制。 毛发上皮瘤 分型： 家族性 多发性 非家族性 单发性 多发性家族性毛发上皮瘤（Multiple Familial Trichoepithelioma） 多发性家族性毛发上皮瘤（MFT）是一种常染色体显性遗传的皮 肤附属器肿瘤 1996年，Harada等对三个美国MFT家系进行连锁分析，将其致病 基因定位于染色体9p21 2004年， 我科收集中国一家三代MFT家系，并将其致病基因定位 于染色体16q12-q13,为CYLD基因 MFT具有遗传异质性 Clinical Feature 临床表现 Grouped tiny pearly papules and nodules on the face, especially,the upper lip and nasolabial folds. Occasionally on the scalp,neck,and upper trunk . color: skin color or yellowish generally begin during early childhood or at puberty. Histological Feature 组织病理 Treatment 治疗 There is no effective therapeusis. Laser Refrigeration Dermabrasion Treatment of MFT With Aspirin口服阿斯匹林治疗多发性家族性毛发上皮瘤 Case Report 病例报道 41-year-old white woman with clinically apparent MFT Physical examination: numerous skin-colored, dome-shaped papules on her entire face and scattered throughout her scalp. During the 15 years she has undergone mumerous laser, but the papales always recurred. numerous skin-colored, dome-shaped papules on her entire face and scattered throughout her scalp. Oral aspirin(325mg twice daily) Subcutaneous adalimumab(40mg every other week) After 2 months: Oral aspirin(325mg twice daily) Subcutaneous adalimumab(40mg every week) 口服阿斯匹林（325mg 2次/日） 皮下注射adalimumab（40mg 1次/2周） 两个月后： 口服阿斯匹林（325mg 2次/日） 皮下注射adalimumab（40mg 1次/周） Eight months later 八个月后 The trichoepitheliomas were smaller and her skin was less indurated. 皮疹变小，皮肤也较前