NIH Initiatives in Diabetes, Obesity and MetabolismNIH的举措，糖尿病，肥胖和代谢.pptVIP

Diabetes, Obesity Metabolism Research in the Early 21st Century* (*from the NIH Point of View) December, 2004 Maren R. Laughlin, Ph.D. Senior Advisor for Integrative Metabolism National Institute of Diabetes Digestive and Kidney Diseases National Institutes of Health Three Major Areas of Interest Diabetes Metabolic Disease NIDDK, NHLBI, NIA, NICHD, NIAID, NCI, NIBIB, etc. Obesity Trans-NIH / /welcome/org/OD/OOR/OOR.htm NIH Roadmap Trans-NIH Diabetes Metabolic Disease* (*from the NIH Point of View) Type 2 Diabetes Incidence: ~18M Americans Healthcare burden: $132B in 2002 Recently found in children and young people as well as older adults Major focus of NIDDK research efforts Type 1 Diabetes Special Statutory Funding Program for Type 1 Diabetes Research /fund/diabetesspecialfunds/funding.htm $1.14 billion for FY 1998 - FY 2008 Diabetic Complications Common to type 1 and type 2 diabetes Heart disease/atherosclerosis, microvascular disease / neuropathy, retinopathy, nephropathy Multi-pronged Approach to Diabetes Research Investigator Initiated Grants Treatment and Prevention Trials Epidemiology Genetics studies Requests for Applications: NIH Initiated Grants Resources, such as Animal models Tissue sources Standards Reagents and technologies Community Organization (consortia, collaberations, workshops, etc) Training Type 2 Diabetes Resources Diabetes Centers: DERCs and DTRCs Provides core resources to foster interdisciplinary research in diabetes and related areas International Type 2 Diabetes Linkage Analysis Consortium Mouse Metabolic Phenotyping Centers (MMPC)Mice are shipped to a Center for in-depth phenotyping Nuclear Receptor Signaling Atlas to gather and organize information relating to key aspects of orphan nuclear receptor biology Type 1 Diabetes Resources cont’d. Islet Cell Resource Centers (ICR) Human Pancreatic Islets Available for Non-Clinical Research ($0.10 / islet) Availability of pancreas-specific microarrays Mouse