b7h1 ki67及肿瘤相关巨噬细胞在胃腺癌组织中表达及其临床意义 word格式.docxVIP

B7-H1、Ki67 及肿瘤相关巨噬细胞在胃腺癌组织中的表达及其临床意义英文摘要Expression and clinical significance of B7-H1, Ki67and Tumor Associated Macrophages in gastric adenocarcinomaAbstractObjective: To study the expression and clinical significance of B7-H1, Ki67 and tumor associated macrophages (CD68+) in gastric adenocarcinoma.Methods: The expression of B7-H1, Ki67 and tumor associated macrophages were detected by immunohistochemistry (SP method) in 100 cases of gastric adenocarcinoma tissues; statistics analyzed the relationship between the expression of B7-H1, Ki67, tumor associated macrophages and clinicopathological features; investigated the effect of B7-H1 and Ki67 on tumor associated tumor associated macrophages in gastric adenocarcinoma tissues.Results: the results showed B7-H1 protein was found in 65 of 100 cases of patients with gastric adenocarcinoma, of which 31 cases appeared expression of nuclear; the expression of B7-H1 protein was positively correlated to lymph node metastasis, pathological staging and survival time ( P0.05 ), and had no correlation with patient’s sex, age, histological type and the invasion depth ( P0.05 ).Ki67 was expression in nuclear, the positive rates were 68%; Ki67 was positively correlated to patient’s age, pathological staging ( P0.05 ), and had no correlation with patient’s sex, histological type, invasion depth and lymph node metastasis ( P0.05 ). tumor associated macrophages expressed in gastric adenocarcinoma patients and英文摘要 B7-H1、Ki67 及肿瘤相关巨噬细胞在胃腺癌组织中的表达及其临床意义 showed oval, satellites or spindle-shaped, the expression of tumor associated macrophages were positively correlated to lymph node metastasis ( P0.05 ), had no correlation to patient’s sex, age, histological type, invasion depth, pathological staging and patient survival time ( P0.05 ).The expression of B7-H1 and Ki67 were positive correlation in gastric adenocarcinoma, the coefficient: r=0.645, P=0.000. B7-H1 and Ki67 affected tumor associated macrophages; compared with negative exp