Lu-T细胞与细胞免疫 2014.pptVIP

3) memory T cells 1) CD45RA-CD45RO+CD44+, 2) Long-lived memory to specific antigen 3) Mediate faster, stronger and more effective immune response 4) Mechanism: low dependent on costimulatory molecules or more sensitivity to cytokines Summary Development of T cells: Markers and stages, Essentials; 2. T cell surface markers: Related to Functions 3. T cell subsets: ?? vs ??; CD4 vs CD8; Ths.. 4. Functions of T cells: Th1, Th2, CTL; 5. Cell-mediated immunity: Activation of T cells Effector of T cells * * * * The thymus is made of lobules, each contains cortical (outer) and medullary (central) regions. The cortex consists of immature thymocytes associated to cortical epithelial cells. The medulla, consists of mature thymocytes. medullary epithelial cells along with macrophages (yellow) and dendritic cells (branched, yellow). * * * * * CD40L主要表达在活化CD4+T细胞、部分CD8+T细胞和?? T细胞,CD40L结合到B细胞表面CD40产生的信号，是B细胞进行免疫应答和淋巴结生发中心形成的重要条件。 * * * * * * ?? vs ?? T cells T-cell response- Na?ve Effector and Memory T cells Na?ve vs memory T cells T cell differentiation 4. Functions of T cells 1. CD4+ helper T cells (Th): Th0:Th cells that secrete broad spectrum of cytokines at low level. Th1: produce IL-2 and IFN-?, but not IL-4. They are chiefly responsible for cell-mediated immune responses, but can also help B cells to produce IgG2a, but not much IgG1 or IgE; Th2: secrete IL-4, 5, 10, 13, but not IL-2 and IFN-?, are very efficient helper cells for production of antibody, especially of IgG1 and IgE . Th17：secrete IL17, 21,22,26 and TNF-?, promote anti-bacteria and anti-fungi response. Responsible for inflammatory and autoimmune diseases Tfh: folicular helper T cells, promote B cell to develop into plasma cell and secrete antibodies Th1 vs Th2 CD4 T cell mediate immunity – effecter functions 2.?CD8+ cytotoxic T cells (CTL) Function: directly kill target cells (cytotoxicity) 3.?CD4+ CD25+ regulatory T cells (Tr) Foxp3 positive Function: