医学免疫学补体系统.pptVIP

Downloaded from: StudentConsult (on 1 June 2006 02:08 PM) ? 2005 Elsevier 不同途径补体系统激活的比较 经典途径 MBL途径 旁路途径 免疫复合物 病原体甘露糖残基 C1、C4、C2 MASP、C4、C2 病原体表面 C3、B、D C3转化酶 C5转化酶 攻膜复合体 Regulation of complement activation 1.Self-regulation C4b2b C3bBb C4b C3b C5b 2.Control proteins classical pathway:C1INH C4bp I MCP DAF alternative pathway: H I CR1 DAF P formation of MAC: C8bp CD59 complement Downloaded from: StudentConsult (on 1 June 2006 04:16 PM) ? 2005 Elsevier Regulation of complement activation complement C1IHN缺陷引起血管神经性水肿 Regulation of complement activation complement Regulation of complement activation complement Regulation of complement activation complement Regulation of complement activation complement Biological function of complement system 1. complement mediates anti-infection immunity (1) Lysis of cell or microorganisms 微生物 (2) opsonization (3) inflammation complement Complement system 补体系统 IMMUNOLOGY Qingqing Wang Institute of Immunology Zhejiang University School of Medicine wqq@zju.edu.cn Complement Contents 1. Introduction 2. Activation of the Complement System? 3. Regulation of complement activation 4. Biological function of complement system Jules Bodet (1870-1961), 比利时科学家 Discoverer of Complement 1894 Bordet 发现绵羊抗霍乱血清能够溶解霍乱弧菌，加热56℃ 30 min 阻止其活性；加入新鲜非免疫血清可恢复其活性。 百日咳杆菌 1919 Nobel Prize Complement 补体（Complement）：新鲜血液中存在一种不耐热的成分，可辅助特异性抗体介导的溶菌作用。 Introduction Complement (C) 补体 A group of serum proteins involved in the control of inflammation, the activation of phagocytes and the lytic attack on cell membranes. This activity is destroyed (inactivated) by heating serum at 56?C for 30 minutes . Complement System? consists of a large number of proteins which become enzymes after being activated. Complement Activation proteins 2. Regulatory proteins 3. Complement receptor Complement Proteins of the Complement System Activation Proteins Classical pathway: C1q,