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31 Biomedical Knowledge Engineering Using a Computational Grid Marcello Castellano and Raffaele Stifini Politecnico di Bari, Bari Italy 1. Introduction Bioengineering is an applied engineering discipline with the aims to develop specific methods and technologies for a better understanding of biological phenomena and health solutions to face the problems regarding the sciences of life. It is based on fields such as biology, electronic engineering, information technology (I.T.), mechanics and chemistry (MIT, 1999). Methods of Bioengineering concern: the modeling of the physiological systems , the description of electric phenomena or magnetic ones ,the processing of data, the designing of medical equipments and materials or tissues, the study of organisms and the analysis of the link structure property typical of biomaterials or biomechanical structures. Technologies of Bioengineering include: biomedical and biotechnological instruments (from the elementary components to the most complex hospital systems), prosthesis, robots for biomedical uses, artificial intelligent system, sanitary management systems, information systems, medical informatics, telemedicine (J. E. Bekelman et al, 2003). Biomedicine has recently had an innovative impulse through applications of computer science in Bioengineering field. Medical Informatics or better the Bioinformatics technology is characte