C–H Bond Functionalization：C–H键功能化精品.pdfVIP

C–H Bond Functionalization Mark Vander Wal MacMillan Group Meeting March 9, 2010 What is C–H Bond Functionalization/Activation ? (C) H R X transition metal catalyst (C) R R = C or heteroatom X = FG or H (C) is sp2 or sp3 carbon atom (C)–H bond is not a traditionally reactive bond (i.e. pka 30-35) Selectivity is a large issue due to the ubiquitous presence