细胞因子与受体课件.pptVIP

* Figure?1. Interferon (IFN) is produced by the plasmacytoid dendritic cell (pDC). Accumulation of RNA-DNA hybrids may be recognized by TLRs in endosomes or by the RNA helicases RIG-1 and Mda-5 in the cytoplasm. The recognition leads to a cascade of signal transduction events, resulting in the phosphorylation of transcription factors (interferon regulatory factors (IRFs)) and the induction of the type I interferon genes. Secreted interferon is recognized by interferon receptors (IFNARs) I and II and induces a cascade leading to the induction of interferon-inducible genes. Many of the interfero