型糖尿病儿童血MIF和MCP水平及临床意义.docVIP

1型糖尿病儿童血MIF和MCP-1水平及临床意义 杨卫霞 徐美玉（南通大学附属医院儿科，江苏南通 226001) 【摘要】目的: 探讨型糖尿病巨噬细胞移动抑制因子（Macrophage migration inhibitory factorMIF）和单核细胞趋化蛋白-1（Monocyte chemoattractantprotein-1MCP-1）以及白介素-18（nterleukin-18，IL-18）。方法：对2011 年11月至2013 年4月在该院就诊的54例1型糖尿病患儿进行MIF、MCP-1、IL-18、糖化血红蛋白、血pH值检测，根据患儿有无酮症酸中毒分为DKA 组和非DKA 组另选25 例正常体检健康儿童作为对照组分析比较疾病不同严重程度、不同病程患儿血中MIFMCP-1、IL-18水平的差异，同时寻找血pH值、HbA1c与相关细胞因子间的关系。结果：1、与健康对照组比较，MIF、MCP-1、IL-18水平在1型糖尿病患儿中显著升高（p0.01），而IL-18在DKA 组中的水平高于非DKA 组，差异有显著性（p0.05）。2、病程小于一年患儿MIF、MCP-1、IL-18水平高于病程大于一年患儿，差异有显著性（p0.01和0.05）。、直线相关分析显示MCP-1与PH 、HbA1c正相关（p0.05），Lg(MIF) 与PH 、HbA1c无相关性（p0.05）结论：MIF，MCP-1、IL-18在1型糖尿病中的水平较正常儿高， 新发病者尤其明显，因子参与了儿童1型糖尿病的发，MCP-1【关键词】1型糖尿病；巨噬细胞移动抑制因子；单核细胞趋化蛋白-1 The serum level and clinical value of MIF and MCP-1 in type 1 diabetes mellitus in children Yeixia，Xeiyu*. Huang Feng，Zhang Xiangdong ,Cai Jin, Shen Feifei （Department of Pediatrics, Affiliated Hospital of Nantong University，Nantong，Jiangsu 226001，China【Abstract】Objective: To study the clinical value of MIF ,MCP-1 , interleukin -18 in type 1 diabetes mellitus (T1DM) in children .Methods: The Serum cytokines and antibody levels were measured in 54 children with type 1 diabetes mellitus diagnosed in the Affiliated Hospital of Nantong University from November 2011 to April 2013．The diabetic children were classified into two subgroups with or without ketoacidosis, another 25 healthy children as control group. Different cytokines levels were compared among different groups according to disease severity and course, at the same time, the relationship between HbA1c, pH and related cytokines were analysised. Results: 您要翻译的是不是：baidutranslate 1, MIF, MCP-1, IL-18 levels was significantly higher in children with type 1 diabetes than that in healthy children (p0.01), and IL-18 was higher in ketoacidosis than that without DKA (p0.05). 2, MIF, MCP-1, IL-18 levels were significantly higher in children with recent-onset type 1 diabetes within one year than that over one year, (p0.01 and 0.05). 3 Linea