Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease（从转录谱推断RNA衰变率凸显阿尔茨海默病的调控方案）.pdfVIP

ARTICLE DOI: 10.1038/s41467-017-00867-z OPEN Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease Rached Alkallas1,2, Lisa Fish3,4,5, Hani Goodarzi3,4,5 Hamed S. Najafabadi 1,2 The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism. We show that in all primary human tissues tested, and part