Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity（纹状体注射α-突触核蛋白可引起广泛的共核病变，不依赖于神经解剖连接。）.pdfVIP

Sorrentino et al. Molecular Neurodegeneration (2017) 12:40 DOI 10.1186/s13024-017-0182-z RESEARCH ARTICLE Open Access Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity Zachary A. Sorrentino1,2, Mieu M.T. Brooks1,2,4, Vincent Hudson III1,2, Nicola J. Rutherford1,2, Todd E. Golde1,2,3, Benoit I. Giasson1,2,3* and Paramita Chakrabarty1,2,3* Abstract Background: Prionoid transmission of α-synuclein (αSyn) a