辅料对青皮配方颗粒喷雾干燥抗粘壁作用效果的研究.pdfVIP

Hans Journal of Medicinal Chemistry 药物化学, 2018, 6(1), 7-12 Published Online February 2018 in Hans. /journal/hjmce /10.12677/hjmce.2018.61002 Research on Effects of Excipients on Wall Sticking Prevention in Spray Drying of Qing Pi Formula Granules * Shanyang Ye, Bijian Ban, Yan Huang , Xizhen Wang, Dongju Wei PuraPharm (Nanning) Pharmaceutical Company Limited, Nanning Guangxi th th th Received: Jan. 14 , 2018; accepted: Jan . 27 , 2018; published: Feb. 6 , 2018 Abstract Objective: Research on effects of different excipients on wall sticking prevention during spray drying process of Qi Pi formula granules. Method: With powder-collecting rate and water content as indicators, the impacts of β-cyclodextrin, CMC-Na and inlet air temperature on spray drying of Qi Pi formula granules are observed by adopting the L9(34) orthogonal design method, so as to optimize key parameters of spray drying process and obtain the optimal excipients ratio and process parameters. Results: Dosage of CMC-Na has significant effect on powder-collecting rate (P 0.05), inlet air temperature has significant effect on water content of dry powder (P 0.05). Conclusions: The optimal spray drying process includes 8% β-cyclodextrin, 2% CMC-Na, 6% dex- trin and inlet air temperature 185˚C. Keywords Orthogonal Design, Spray Drying, Formula Granules, Qing Pi 辅料对青皮配方颗粒喷雾干燥抗粘壁 作用效果的研究 * 叶善洋，班必剑，黄 艳 ，王熙珍，韦冬菊 培力(南宁)药业有限公司，广西 南宁 收稿日期：2018年1月14 日；录用日期：2018年1月27 日；发布日期：2018年2月6 日 *通讯作者。 文章引用: 叶善洋, 班必剑, 黄艳, 王熙珍, 韦冬菊. 辅料对青皮配方颗粒喷雾干燥抗粘壁作用效果的研究[J]