汉防己甲素与克矽平联合治疗矽肺远期疗效观察.doc

汉防己甲素与克矽平联合治疗矽肺远期疗效观察 ? 116?环境与职业医学20O2年4月第】9卷第2期ChinJEnvinmOccIMed.Apr2O02Vot19No2 文章编号:1006-3617t2002)ff2-011604中国分类号:R1352文献标识码:A 汉防己甲素与克矽平联合治疗矽肺远期疗效观察 【职业病防治】 周泽深,王飞云.胡一本,孙垒礼,孙文灏.彭娟娟,闻军,胡天锡,李学祯.蔡铁安,谷圣常 摘要:[目的]病人按国家”八?五”课题《矽肺治疗措施及鼓果评伊研究》的汉防己甲素和克矽平联合沿疔矽肺的 的继续治疗观察.[结果]垒量组和维量组的症状好转率较停药组和对照组高,尤其是呼 吸困难症状.x线胸片垒量组有明显好转病例2饵,有进展的病例也较其他组少.好转病例仍集中在过去接触高浓度 矽尘的病例.停药后病变出现反跳的经继续用药,可好转.不良反应较轻.[结论]汉防已甲素和克矽平联合用药治 疗矽肺可提高疗效,降低不良反应. 关键词:矽肺;汉防己甲素;克矽平 TheLong.termEffectsofCmnbinafionTherapywithTetrandrineandPVNOinSi吐00sisPa6蚰bZHOU Ze-sheWANGFei-)v~.x,HUY~-ben,SUNjin—SL~’VWen—h,w,PENGJ㈣俩,WEN’,HUTian-xi’, 12Xue一:,CA1Tie-an,GUSheng-clumg(1.ShonghaiOccupationalDiseaseHosphal,翰咄200433,Chi— w:2.1z=hongMaa~urgicdMiningCompanyHospita1) Abstr~t:[Objective]St~dDng】elong—termourativeeffectsOllthesilicosispatientstreatedpr~,iouslyfirstinaccordingtothe national”8?15”p”~vayi.gOllTherapy0dandCurativeEffectsfarSilicosisofCombiaationTherapywithtetranamp;ine(Tr)and —yy缸e-山(PO)fortwoyears,thenstop#,tgtherapyforoIleyeararidthencontinueingtherapyagain[Methods]All thesep衄bweredi~ddedintofourgroupsaccaMingtothechestX-rayresult:(!)off,hald0sgegroup:TT200ms/day,6daysper week;1%P~q’qO144mlwasdintobronchithroughfibrobmnchiendoscopetorlp~-ayear.②conliauousd0sage~cmp:TI”100mg 3timesperday,onedayperweek③therapy-ceasedgrouparm④contmlgroup;take4placebotablets,or.ceaweek.Acoui”$~oftreat— merittakesthreemonthsandwith0rIe-Ⅱin~’valhetweentwocaⅡses,alltogethersixCOlllr~scarriedoutduringtwoyeats.[Resvl~] Itw衄higherthatthesymptomsmendedinthe胁andsecondgroup.especiallyforthesymptomofd)qm∞Therewassignificantim— plw.,emertto/1chestX-rayfilmf2easesinthefirst舯up.Numberofca,,a~s~,Sthadvarcingofdiseaseinthefirstgrouparelessthan thatinocherthreegroups.Improvedcaseswereconcentratedinheavilyexp,,~edgroup.Patient’sconditionwasimprovedaftermedical therapy_n,ifhisconditionwasrebourdafterinterruptedtherapy.Thesideeffectandtoxicity0fthiskindoftherapyisb出.【Con’ cIl蓐bn]Tetrandrineand/z,rb-oinc0n砌ti帅forsL!ieo~isthera~rhavebetterceffectsandhad