最新天麻钩藤饮治疗高血压病的系统评价.pdf

中文摘要 目 的：系统评价天麻钩藤饮治疗高血压病的临床疗效。 方 法：根据制定的检索策略全面收集有关天麻钩藤饮治疗高血压病的随机临床对 照试验文献，根据JADAD 文献质量评分表逐一评价，筛选出能够真实反映临床疗效 的合格文献，并用RevMan5.0 软件进行Meta 分析 结 果：33 篇随机对照试验满足纳入标准，共有病人4058 例，平均样本数为 123 例。所有纳入研究均未报道如何确定样本量的依据，样本量如何计算等问题。Meta 分析结果：降压疗效有效率OR 合并=2.55,95%CI 的范围为（1.98-3.29) ，提示观 察组优于对照组；症状疗效有效率OR 合并=5.51,95%CI 的范围为（4.30-7.07）。提 示观察组优于对照组；治疗后收缩压的MD 合并=-5.05,95%CI 的范围为（-8.16— -1.94），提示治疗后观察组收缩压改善情况优于对照组；治疗后舒张压的MD 合并 =-4.47,95%CI 的范围为（-7.50，-1.45），提示治疗后观察组舒张压改善情况优于 对照组；天麻钩藤饮可能在改善高血压病患者的降压疗效、症状疗效、治疗后收缩 压、治疗后舒张压指标方面具有一定的效果。但是通过漏斗图分析，提示存在发表 偏倚。 结 论：根据本系统评价的结果，目前还没有足够的证据支持临床常规应用天麻钩 藤饮治疗高血压病，仍需要进行大规模、多中心、高质量、随访时间足够的随机对 照双盲研究以提供证据。 关键词：天麻钩藤饮； 系统评价； 高血压病 The systematic evaluation of treating hypertension by gastrodia uncaria drink Abstract Purpose:To systematically evaluate the clinical curative effect of treating hypertension by gastrodia uncaria drink. Method: According to the retrieval strategy, to comprehensively collect randomized controlled clinical trials literatures concerning the treatment of hypertension by gastrodia uncaria drink; to evaluate separately according to the score sheet of JADAD quality of literature, filter qualified documents which can really reflect the clinical efficacy; and to conduct analysis by using the Meta analysis RevMan5.0 software. Results: 33 randomized controlled trials meet the inclusion criteria, with a sample of 4058 patients. And the average number of samples is 123. All studies included did not report how to determine the basis of sample size, and problems such as how to calculate sample size. Results of Meta - analysis: hypertension treatment effectiveness OR merge = 2.55, the range of 95% CI is (1.98 3.29), the observation group is better than the controlled group; Symptoms curative effect efficiently OR merge = 5.51, the range of 95% CI is (4.30 7.07). The observation group were better than the controlled group;