复方木鸡颗粒治疗乙肝肝纤维化疗效观察.docVIP

复方木鸡颗粒治疗乙肝肝纤维化疗效观察 王丽 徐州市中心医院感染性疾病科 221009 【摘要】目的：观察复方木鸡颗粒治疗乙肝肝纤维化的临床疗效。方法：将126例伴血清肝纤维化指标异常的慢性乙型病毒性肝炎患者随机分为治疗组与对照组，前者给予复方木鸡颗粒治疗，后者给予大黄蛰虫丸治疗，两组疗程均为6个月。结果：与治疗前比较，治疗组治疗后血清肝纤维化指标和甲胎蛋白明显下降(P0.01)；与对照组治疗后比较有显著性差异(P0.05)。治疗组与对照组总有效率分别为82.4%、60%(P0.05)；治疗半年，治疗组与对照组总有效率分别为89.7%、66.7%(P0.05)。结论：复方木鸡颗粒有较好的抗肝纤维化、降低甲胎蛋白和改善肝功能作用。 【关键词】 慢性乙型病毒性肝炎；肝纤维化；复方木鸡颗粒 Observation of Therapeutic Effects of Compound Muji Granules in the Treatment of Chronic Hepatitis B with Hepatic Fibrosis Wang Li Department of Infectious Diseases, Xuzhou Central Hospital Affiliated to Dongnan Medical University, Xuzhou City, Jiangsu Province, 221009, China Email: awj922@ 【ABSTRACT】 OBJECTIVE To observe the therapeutic effects of Compound Muji Granules in treating chronic hepatitis B with hepatic fibrosis. METHODS 126 cases of chronic hepatitis B with hepatic fibrosis were randomly divided into two groups: treatment group and control group. The treatment group was treated with Compound Muji Granules while the control group was treated only with Rhubarb and Eupolyphaga Pellet, each for a treatment course of six months. RESULTS In the treatment group the serologic parameters of hepatic fibrosis and AFP declined significantly after treatment (P 0.01). There were significant differences compared with the control group (P 0.05). The overall efficacy rates in the treatment group and the control group were 82.4% and 60% (P 0.05) respectively. At the end of six months, the overall efficacy rates in the two groups were 89.7% and 66.7% (P0.05) respectively. CONCLUSION Compound Muji Granules could resist hepatic fibrosis、decrease AFP and improve the hepatic function in chronic hepatitis B patients obviously. 【KEY WORDS】 Chronic hepatitis B; Hepatic fibrosis; Compound Muji Granules 在慢性乙型病毒性肝炎(Chronic hepatitis B, CHB)中,肝纤维化的防治占有重要地位。本研究观察了复方木鸡颗粒抗肝纤维化的治疗效果。 1 资料与方法 1. 1 临床资料 2006年2月～2007年6月我院门诊和病房患者126例，临床诊断标准按2000年(西安)第10次传染病与寄生虫病学术会上制定的《病毒性肝炎防治方案》[1]拟定。所有患者的肝纤维化指标至少有2项持续异常达3个月以上。随机分为治疗组与对照组。治疗组66例中，男性44例，女性22