替米沙坦对实验性糖尿病心肌病大鼠心脏保护作用的研究-心血管内科专业论文.docx

硕士学位论文英文摘要An ExPer加entalStu dy on theCardiacProtectiveEffe etsofTelm isartan on DiabeticCardiom yoPathyinR stSAbstractA im T o investigate eardiac Proteetive effe ctsand itsPossiblem echalil sm of tel而sartan on diabetie card iom yoPa而c rats;and toexPlore the effe ctsoftel而Sartan on exPression ofN F一K B ，ICA M 一1 andM CP一1 inthem yoeardiumof diabetieeardiom yoPathieratsanditsPossiblecardiaeProteetive effectsm eeh耐sm s.M ethods Studies w ere done in 42 m ale SPrague一D aw lay ratsweighing 180一2009.Ofthese，30ratsreceivedasingleintraPeritonealinjection ofSTZ(55mg/kg)dissolvedinsodiumcitratebuffer，andtheremainingratsreceivedan injeetionofbufferandservedasnondiabeticeontrols (『ouPC，n=12).After 4weeks later，thecardlaemuseleultra而eros曲cture ehanges accords w ith thediabetieeardiomy oPathy，s，indicatin gthat diabeticcardlom yo Pathym ode ls w ere establlshed.Th ediabetic cardiom yoPathy rats w ere ran dollilydividedintofollow ingZgrouPs:untreatedDCMrats(grouPDCM ，n=12)，DCMratstreated withTel而sartan[ZOmg/(kg’d)]for8weeks(grouPT，n=12).A tthe end ofthe exPerim ent，LV M Iand he叭function w ere翌塑丝乙一一一一一一一一一一-二荞文钾要deteeted and the cardlacmu seleultrastrueturew asobserved toinvestigatecardiac一Protective effeetsofte俪s叭an on diabetiecard iom yoPathy rats.Im m unohistochelnicaltec俪quesw ereused to deteetN F一KB activation ，ICAM 一l、M CP一1exPression .R esults A fter s一w eek tel而sartan treatm ent，the levels ofLVM I，LVEDP，t一dP/dtwasincreasedmarkedly(allP0.0万).ComParedw ith starch grouP，w hile LV SP ，+dP/dtma、，一dP/dtfna、w as decreased11十蚤一八markedly(all P0.0万).Rarefaction，fragme ntation，deran gem ent 0Om yoeardlum m yofibril，Prollferation，tume faction，degeneration而tochondria，disruPtion，rarefaction ofInitoehondrion ridge，dePositionofglyeogen，hyPerplasiaofeollagen in interstitialw ere observed underelectro n InicroscoPe.Allthe above ehanges in the tel而s叭an grouPdiabCticmtsw CreleSSob vious.A lldthecon