贝特类药物在血脂治疗中作用.pptVIP

Fibrates: introduction The fibrates available in the United States are clofibrate, gemfibrozil, and fenofibrate. Changes in potency provide similar effects at lower dosages: clofibrate is usually administered at 1000 mg BID, gemfibrozil at 600 mg BID, and fenofibrate at 200 mg/d in a single dose. Other fibrates available in other countries are bezafibrate and ciprofibrate. Concerns about the long-term safety of fibrates arose with publication of the results of the World Health Organization Cooperative Trial in 1978 and 1980, which showed an increase in all-cause mortality with clofibrate.