a-heft研究, peace研究与rio-na研究ppt课件.pptVIP

RIO-NA: Results At one year, patients taking 20-mg rimonabant had significant reductions in waist circumference, body weight, triglycerides Insulin sensitivity improved and HDL levels rose Second part of the study disappointing; at one year, if you discontinue dose, the weight comes back Changes in lipid parameters and insulin resistance were out of proportion to weight loss RIO-NA results Change in Placebo 5-mg rimonabant 20-mg rimonabant Weight (kg) -2.8 -4.4 -8.7 Waist circumference (cm) HDL (mg/dL) -3.9 +7.2 -4.7 +9.3 -8.2 +16.1 Triglycerides (mg/dL) +4.1 -0.6 -11.5 Metabolic syndrome