基于遗传算法dna计算编码序列设计-控制科学与工程专业论文.docx

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基于遗传算法dna计算编码序列设计-控制科学与工程专业论文.docx

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基于遗传算法dna计算编码序列设计-控制科学与工程专业论文

0BABSTRACTInthispaper,mainlyintroducesthebackgroundknowledgeofDNAcomputing,whichbecomingresearchhotspotincomputer,mathematicsandbiologyfield.TheresearchsituationofDNAcomputing,DNAcomputing’sprincipleandcorrelativebiologyknowledgearealsointroduced.Ahybridoptimizationmethodbasedongeneticalgorithmandculturalalgorithm(HGCA)isdevelopedtosolveDNAencodingproblem.Thismethodbasedonfactorsandrestrictions,whichaffectencoding.Thendevelopedanestimatemodeltoestimateencoding’squality.Thedetailedcontentsareasfollows:Firstly,summarizedDNAcomputing’sresearchsituationandDNAcomputer’sresearchevolvement.DNAcomputinghasbecomingaresearchhotspot,becauseofDNAmolecule’smassiveparallelism,high-densitystorage,andenergyefficiency.Secondly, encodingproblem, whichisthe coreproblem in DNAcomputing, hasbeenresearched.InDNAcomputing,theinformationisalwaysrepresentedbyuniqueDNAsequencesanditsprocessingisaccomplishedthroughthespecialhybridizationbetweenthoseDNAsequences.Thereby,thepivotalprobleminDNAcomputingistheencodingproblem.TheresearchinthelastdecadehasshownthatencodingproblemisacrucialprobleminDNAcomputing.Firstly,itdirectlyaffectsthesyntheticqualityofDNAsequences;Secondly,theencodingimpactsdirectlyonhybridizationwhetherornotinaccordancewiththedesigngoals;Thirdly,qualityofencodingnotonlyaffectsdirectlythesizeoftheirspace,butiscloselyrelatedtothein-depthdevelopmentofDNAcomputer.Then,discussedtheDNAencodingsequencesdesign.DNAencodingproblem,whichhasbeenprovedtobeanNP-completeproblem,isacrucialproblemforDNAcomputing.Itisusuallysolvedbyoptimizationalgorithm.Aimingatthedisadvantagethatlackofefficientguidanceandeasytogetintolocalextremum,whichbelongtothetraditionalgeneticalgorithm,socombiningculturalalgorithm,usingthedoubleevolutionframepopulationspaceandbeliefspacetooptimize,developingahybridoptimizationmethodbasedongeneticalgorithmandculturalalgorithm(HGCA)tosolveDNAencodingproblem.SimulationresultsshowtheefficiencyofHGCA.Atlast,basedondiscussingtheconstraintsabouttheDNAsequenceencodingdesign,five e