脑钠肽(bnp)与心力衰竭的研究进展-教学课件.pptVIP

脑钠肽(BNP)与心力衰竭的研究进展 北京世纪坛医院 北京大学第九临床医学院 杨水祥 教授 2009年8月20日 Outcomes in Patients Hospitalized With HF Potential Deleterious Effects of Diuretics and Cardiorenal Syndrome of HF Natriuretic Peptides:The Heart as a Secretory Organ Atrial stretch receptors link blood volume to renal function Distension of a balloon catheter in atria of dogs resulted in diuresis Henry et al (1956) Secretory granules discovered in the atria Kisch (1956) Jamieson and Palade (1964) BNP was characterized by amino acid sequence and DNA clones Sudoh et al (1988) Seilhamer et al (1989) Natriuretic Peptides Natriur