关注出血合理选择抗凝治疗 郭丽君.pptVIP

关注出血合理选择抗凝治疗 北京大学第三医院 郭丽君 ACS的病理解剖学基础 抗凝药物的作用部位 Bivalirudin 20 Amino acid polypeptide Direct thrombin inhibitor, not AT dependent Short-half-life of 25 minutes Effective on circulating and clot-bound thrombin Inhibits thrombin-mediated platelet activation No interactions with PF-4 No requirement for anticoagulant monitoring Not associated with HIT ExTRACT-TIMI 25 30天临床净获益依诺肝素具有显著的优势 REPLACE-2 PCI Trial The ACUITY ACS Trial (N=13819): Components of the Ischemic Composite The ACUITY Trial (N=13,819):Predictors of Major Bleeding in ACS OASIS 5: Efficacy and Safety at Day 9 Primary Efficacy O