epa dha改善胰岛素抵抗与改善炎症的相关性研究word格式论文.docx

目录中文摘要········································································································1英文摘要·································································································6英文缩写······································································································12研究论文EPA、DHA改善胰岛素抵抗与改善炎症的相关性研究前言······································································································13材料与方法··························································································14结果······································································································20附图······································································································23附表····································································································32讨论····································································································36结论······································································································40参考文献·····························································································41综述消退素的研究进展··········································································44致谢·······································································································53个人简历········································································································································54EPA、DHA改善胰岛素抵抗与改善炎症的相关性研究摘要目的：胰岛素抵抗（insulinresistance，IR）是指胰岛素敏感组织（如脂肪组织、骨骼肌、肝脏）受胰岛素介导的葡萄糖摄取和利用效能减低的一种病理生理状态，为了维持血糖的稳定，机体代偿性的分泌过多胰岛素产生的高胰岛素血症。胰岛素抵抗是多种代谢性疾病（如糖尿病(diabetesmellitus,DM)、肥胖、高脂血症、高血压）发病的共同病理生理基础。目前研究表明，胰岛素抵抗是一种慢性低度炎症反应性疾病，深海鱼油（（二十碳五烯酸（eicosapentaenoic acid，EPA）、二十二碳六烯酸（docosahexaenoicacid，DHA））可以改善胰岛素抵抗，但其作用机制尚不十分明确。鱼油是否是通过抗炎作用来减轻胰岛素抵抗的？其抗炎作用机制是什么？与其衍生物消退素和其受体结合后引起的细胞信号途径转导是否有关？为了明确上述问题，我们开展了此项研究。方法：选取河北医科大学第二医院2014年12月至2015年12月就诊的2型糖尿病患者31例。其中，男12例，女19例，年龄32-74岁，平均年龄为5