POLYBROMINATED DIPHENYL ETHERS IN HUMANS–SOURCES AND EXPOSURE.docVIP

POLYBROMINATED DIPHENYL ETHERS IN HUMANS – SOURCES AND EXPOSURE O.I. KALANTZI, P.A. SISKOS Environmental Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupoli, 157 71 Zografos, Athens, Greece Email: okalantzi@chem.uoa.gr EXTENDED ABSTRACT Polybrominated diphenyl ethers (PBDEs) are a class of widely used flame retardants that are incorporated into a wide range of consumer products such as household appliances, plastics, textiles and computers, to prevent fire. They were first introduced in the environment in the 1970s and their concentrations have been increasing ever since. Their persistence in the environment, widespread distribution and bioaccumulation in humans and wildlife has rendered them chemicals of concern. The main route of entry of these chemicals into the human body is via the food web, but occupational exposure may also occur in the workplace during handling, repair and dismantling of flame retarded goods. Inhalation of indoor air may also be another important route of entry of PBDEs into humans. PBDEs structural similarities to better known and studied chemicals like PCBs are causes for concern. Individual PBDE congeners have been associated with neurotoxic effects following neonatal exposure in animals and effects on thyroid hormone function. PBDEs have also been associated with non-Hodgkin’s lymphoma in humans and a variety of cancers in rodents. They do not appear to be genotoxic, however, there are still many toxicity gaps, including their carcinogenic potential and human effects. This paper reviews the sources and exposure of humans to PBDEs, highlighting recent scientific data. Key words: polybrominated diphenyl ethers, environmental levels, human exposure sources 1. INTRODUCTION In the last century a large number of chemicals were introduced into the environment. Organochlorine pesticides such as 2,2-bis(4-chlorophenyl)-1,1-trichroloethane (DDT), polychlorinated biphenyls (PCBs) and po